Chicago Med Season 10, delves into the intensified challenges faced by the staff at Gaffney Chicago Medical Center following the closure of a neighboring hospital. The emergency department grapples with an overwhelming influx of patients, leading to the appointment of Dr. Caitlin Lenox (Sarah Ramos) as co-chief alongside Dr. Dean Archer (Steven Weber), resulting in leadership tensions. Newcomer Dr. John Frost (Darren Barnet) joins the team, while Dr. Crockett Marcel (Dominic Rains) departs after confronting personal trauma. The season features high-stakes medical cases, including a commuter ship capsizing, a rockslide at a disciplinary camp, and the separation of conjoined twins. Personal storylines unfold with Dr. Charles (Oliver Platt) facing a family crisis, and Dr. Asher (Jessy Schram) exploring surrogacy. The finale, "...Don't You Cry," sees Goodwin enforcing difficult staff cuts, Charles' daughter hospitalized after a car accident, and a transplant patient making a life-altering decision.